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Acknowledgements We would like to thank the Global Facility Center at Hokkaido University for allowing us to use its mass spectrometer, and especially Ms

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However, this finding was consistent with previous reports showing that CCP1-2 domains contain the binding site on C4bp to many pathogens ( We have also shown that an antibody response against the NTD, containing the C4bp binding motif (Pep1), was undetectable if mice were immunized with FL-CSP suggesting that the repeating identical immunogenic determinants within the central repeat domain can mask immune responses to other CSP domains